Someone said :
A species of super bees will emerge, who resist to all of those.
The downside is that they may not be the domestic bee.
Man will not know how to deal with a bee that refuses to be domesticated.
Not necessarily besides no bee is domesticated, they are still a wild insect they could live without man, not like some of the domesticated farm animals which depend on man for their survival.
Take the African bee, they where introduced to south America as they produce more honey then the south American bee, they also reproduce earlier then the American bee which meant they now dominate right up to Texas at a cost to the natural American bee. African bees are the most aggressive bee but they have also been very successfully farmed.
But they to are suffering colony collapse.